Better Assess Cellular Responses to Drug Interactions

Agilent Technologies introduced the most up-to-date whole-genome oligonucleotide microarray for the study of the rat, an organism widely used in the field of toxicogenomics. With probes for more than 41,000 unique genes and transcripts, the Agilent Whole Rat Genome Oligo Microarray provides the broad genome coverage, validated genomic content and sensitivity researchers need to better assess the effect of environmental toxins or drug interactions on cells. Each microarray features highly sensitive 60-mer oligonucleotide probes, which allow increased detection of low-expressing, or rare, genes. Researchers want to identify a toxic response as soon as possible, and this sensitivity enables the identification of changes in toxic response pathways earlier than previously possible. These new microarray probes are based on recently released sequence information from the public genome databases RefSeq, UCSC GoldenPath, Ensembl, Genbank LocusLink, Homolgene and UniGene. To ensure optimal performance, approximately 70 percent of the probes have also been validated empirically. Each rat microarray (G4131A) comes with a customizable region where customers can add their own sequence content using Agilent's eArray portal.